| 翻訳と辞書 |
| inflammatory reflex ： ウィキペディア英語版 |
inflammatory reflex
The inflammatory reflex is a neural circuit that regulates the immune response to injury and invasion. All reflexes have an afferent and efferent arc. The Inflammatory reflex has a sensory, afferent arc, which is activated by cytokines, and a motor, or efferent arc, which transmits action potentials in the vagus nerve to suppress cytokine production. Increased signaling in the efferent arc inhibits inflammation and prevents organ damage.
==Molecular mechanism==
The molecular basis of cytokine-inhibiting signals requires the neurotransmitter acetylcholine, and the Alpha-7 nicotinic receptor receptor expressed on cytokine-producing cells. The release of acetylcholine in spleen suppresses the production of TNF and other cytokines which cause damaging inflammation. Signaling in the efferent arc of the inflammatory reflex, termed the "Cholinergic anti-inflammatory pathway," provides a regulatory check on the innate immune system response to invasion and injury. The action potentials arising in the vagus nerve are transmitted to spleen, where a subset of specialized T cells is activated to secrete acetylcholine.〔Mauricio Rosas-Ballina, Peder S. Olofsson at al. "Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit." ''Science.'' 2011 Oct 7;334(6052):98-101. PMID 21921156〕 The net effect of the reflex is to prevent the damage caused by excessive cytokine production.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「inflammatory reflex」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|